I've been convinced for years that Izzo intentionally teaches his perimeter players to constantly hand-check and reach, knowing that the risk/reward benefit is worth it: For every foul that is called, there are probably 20 other plays where that kind of approach led to a game advantage. Over the course of a complete game, the balance is in the favor of the team.
A similar analogy would be the defensive backs under Pete Carroll. I'm convinced they are taught to grab and molest receivers regardless of what the refs do, knowing that, overall, it led to an advantage over time.
The other nuance to this is that the refs are human - psychologically, they will adapt and begin to become numb to what's going on. It becomes the "norm" for that game.