Michigan's D looked horrible last year too ... and yet they made life for Iowa's O rather difficult. Iowa need to rely on big plays to Moeaki in order to score.
I anticipate that a good Michigan game-plan on D could make things difficult on O. However, the key is that the Hawks need to make sure that they don't get caught playing "catch up." If the Hawk O is given a chance to make adjustments but still remain within the context of their offensive game-plan ... then they should be okay.
Hawk fans should expect a tough, hard fought game ... and then be pleasantly surprised if we can manage to pull away from the Wolverines like MSU did.
However, as other posters have rightly pointed out ... there's no way that Iowa can expect to get picks in the red-zone like MSU got. Furthermore, there's no way that we can expect to rattle off that many 40+ yard runs.
Lastly, it's ridiculous to claim that Denard Robinson got pwned ... he still accounted for something like 300 yards on O for the Wolverines. Most teams would be tickled pink if their QB could be so productive. The catch-22 for Michigan is that Denard IS their O for the most part!