Here's what I got from watching the video of the interview, and I'm surprised others haven't said anything to this effect:
It seems like Clayborn just straight up forgot about Iowa State. If he was trying to make a dig, he would have had more of a smile/wink type of demeanor. He wasn't trying to hate. Someone just asked him a question about the high expectations for Hawkeye football this year, and not one single neuron in his head made the connection between "high expectations" and "Iowa State." (I know, it's outrageous!) So he tried to answer the best that he could, fumbled over his words a bit as many people do in a live interview, and the thought of Iowa State just never crossed his mind.
I think this is the thing that really irks the ISU fans. At least if Adrian was poking fun at the Cyclones, then that would mean that he was at least paying attention to them. But ISU doesn't even register in his mind when thinking about hopes for Iowa's 2010 season. Clayborn is from St. Louis, a pro sports town. So he comes to the UI and sees that the Hawkeyes are THE TEAM that people pay attention to in most of the state. He tries to express that dynamic which he has witnessed here the last few years, but ends up misspeaking. I mean shoot, he's a football player, not a Shakespearean actor. Much ado about nothing.
That's the real story here. Clayborn was able to "put down" ISU without even trying. (And, for the record, without even being asked about the Cyclones.) AC and all the other Hawkeyes will be giving Iowa State all the appropriate attention they need from September 5 to September 11, and then they will move on.