Agree with several viewpoints but this one, especially.
Anything that requires precise execution / timing between pulling linemen and ball carrier has been a disaster. Anything that takes time to develop - jet sweeps, reverses, tunnel screens, even drop back passes - has been unsuccessful.
Right now, Iowa's best offensive scheme is all-in man blocking, downhill rushing, and quick slant passes. Whatever gets the ball out of the QB's hands as quickly as possible, moves forward rather than laterally, minimizes gap vision / decision making, chips away and keeps the clock running. Eliminate all drop-back passes. If you go shotgun, the QB's must be coached to run after 3 seconds and that RB needs to be ready to lead the way. You've got interchangeable QB's, so, injury is a secondary concern with them running more.
Sure, it'll more often than not result in a punt, it's no different than now. I believe it would lead to more opportunities to bust open a play, certainly a few more first downs, eliminate negative yards (sacks and blown-up lateral plays) and, maybe, build a little toughness / confidence.
Above all, keep the clock moving, rest the defense as much as possible, keep the opponent on their end of the field and let the defense make some plays to shorten the field for the offense.