The way to win in the the Big 12 isn't to try to do what the "Big Boys" do, but with lesser talent. You do what Hayden did at Iowa. He knew he couldn't go toe to toe with Mich and OSU in the power run game, so he introduced the forward pass. Chuck Long became one of, if not the only player at the time, to pass for over 10,000 yds in a career and we ended up becoming the third best team in the B1G over Hayden's time. No one in their right mind would have predicted that in 1979.
With ISU, what they need to do is go to a power running game. It doesn't have to be a Navy triple option....but maybe an Alvarez-type offense. They're in the Midwest, so they can certainly get the type of Oline they'd need. And good running backs are a dime a dozen. But that'd at least give them some ball control on offense to limit possession time of the high powered offenses in the Big 12. But if they keep trying to go shotgun, spread, zone read...they're going to keep sucking.