Thats an interesting question. My first reaction (having never studied MICHs film) would be "no".
I dont think the MICH O-line is getting to the second level as much as its just DRob getting into open space and making things happen with his speed and athleticism.
If I were game-planning for DRob, I would line my DEs out wide (1 step) and 2 LBs in the gaps betwenn the DTs and DEs (in standard LB depth). Let my DEs get up field, forcing DRob to stay between the tackles, if he decides to run.
I think our D-line is quick enough to close the gaps between the tackles and the LBs are fast enough to clean it up. Let DRob take some hits for his decisions.
Thats how I would do it.
Of course, I'm sitting here on a message board, so, what do I know?
I honestly don't think Michigan's Oline gets enough credit. Sure, after the first level, it's all Denard but they have to get him there. Their Oline is definitely one of the better, if not the best the Big Ten has to offer at this point. I'm not saying they can control the LOS against Iowa but if they can't, I don't see anyone else doing it either.
I also don't think MSU can set a blueprint for Iowa. MSU's strength is the linebackers, specifically Greg Jones and Iowa's is the Dline with their weakness probably being linebackers.