I think this game (and this season) is going to be a lot like '09. Iowa is coming in to the game bummed out from a "bad" win last week, and Iowa State outperformed expectations last week. ISU will be picked by most people to beat the spread and maybe beat the Hawkeyes, but it won't happen. Iowa will open up a double-digit halftime lead and cruise to at least a 24-point victory.
My prediction:
Iowa 37 (missed XP, made FG)
Iowa State 10