I saw an article recently about the pro game explaining how "base" (7 LB/DL, 4 DBs) is no longer base in the NFL. This defense only accounted for about 30% of defensive snaps in the pro-game, while nickel (5 DBs) accounted for 51% of the snaps. They talked about how this was trickling up from the college game, where even more teams are using 5-6 DBs the majority of the time to combat spread offenses.
As Icke said, Iowa has done a lot more nickel and dime the last few years. It will be interesting to see if they get even more creative with personnel packages this year with an experienced back end, along with relative inexperience at WLB and DE. It is not really in their nature, but it seems like they have the tools to potentially pull it off.