The one thing about computer simulations is they don't take into account momentum. Momentum, especially in college sports, is such a huge factor. It can't be accounted for, especially in the beginning of the year, but there's no denying it's impact on results.
For example, there's no way we win that 2009 game at MSU if we hadn't already won our first 7 games and had momentum on our side.
On the flip side, when you don't have momentum or you lose it after an extended layoff, it's very damaging as well. For example, the 2002 team had no business losing to USC by 3 touchdowns. Had that game been played the week after we destroyed Minnesota to finish 8-0 in conference, there's no way the result is the same.
What I'm getting at here is that I think, based on the schedule, Iowa has a great chance to build some early momentum before the real meat of the schedule hits starting with a road game at MSU. It's not out of the realm of possibility that we could be going to East Lansing with a 5-0 record. If (and it's a big "if", I know, but the schedule the first 5 games is so ridiculously soft and every game, save the 1st one in Chicago, is at home) we can go there 5-0, we have a much better chance to steal that game, based on momentum, than if we went in there at, say, 3-2.
The computers, obviously, don't take that into account and that's why I don't put a lot of stock into them.