If I were Urban Meyer, I would not bother doing anything new, at least schematically, against Iowa. Nothing has changed (other than some personnel) so whatever he's prepared for in the past should still be applicable. If anything, he could use this as an opportunity to try out a few plays/formations that they might be using against Michigan and/or Wisconsin should they meet in the Big Ten championship game. But that is not very likely, given there's no need to tip his hand to any future opponents in order to beat Iowa.
One thing I expect is he will be pouring it on until the end, he has to make a statement against Iowa in order to enhance his CFP chances. A 2 TD victory margin is not going to get the voters' attention and vault them over Oklahoma if Oklahoma beats Oklahoma State this Saturday. Time is running out for him and he does not want anything (including a tight victory margin) impeding his team's final position in the poll. If they win out, maybe he has little to worry about, but right now he has some work to do.