Not that it matters in the scheme of all things, but should Missouri exit the state of Iowa would no longer be contiguous to any member state of the Big 12. Kansas would be the closest state. The conference would be down to just three AAU members; Texas, Kansas, and ISU and there are no candidates in the mix that are AAU members.
The conference will probably hang together, but ISU is increasingly is in an awkward position. Academically it has to compete with members that are not tier 1 institutions and geographically it really has no conference rival. If the conference looks east for members none would be from states contiguous and if they look west it is the same story.
Iowa State wrestling would be down to competing with just two other schools, the Oklahomas. Lots of repercussions from events like this that get overlooked.