Possible. But you would need to quarantine hundreds of D1 football players on their campuses and then have them travel to the game site, hope that none of them have been exposed to the virus. And there you'll have 50-60 athletes each game getting in close contact with each other, breathing, coughing, sneezing, touching each other. I dunno ... just hard to picture it.
It is hard to picture. Logistically it would be extremely difficult. And if one player would get infected, its over.