I don't think so, matchup wise. The last time they played Iowa, it was 59 - 57 Wisky, and they score a similar number of points this year.
Iowa State is pretty deep this year, and they've been scoring in the high 70's low 80's in each game. Iowa can score on most teams, but they have trouble when playing other high-powered offenses - they tend to have defensive issues.
I like Iowa a lot more against a team that likes to slow it down, because it only takes three or four turnovers and the Hawks have a good lead, while the other team already has limited possessions due to style of play. Yeah, Wisconsin may have a good night and keep Iowa below 65, but they rarely get out of the fifties themselves. Iowa State can take advantage of Iowa's weakness defensively in a much bigger way.
I say I'd be concerned if Wisky beats Iowa, because it would mean that the defense hadn't really improved at all, so Wisconsin got to run the whole game their way and the final ended up in the mid fifties. It has bigger repercussions, due to who they will play the rest of the way, to the rest of the season than ISU, who is capable of blowing the doors off of any poor defensive team, though not necessarily capable of beating a better balanced team outside of Hilton. If Wisky controls the tempo, same ol Hawks.