Yes, you can pick the moneyline on parlays. Picking favorites to win doesn't pay out as much though. Those Vegas guys aren't stupid! I don't do alot of parlays until football. When you type in your bet you can see how much your payout will be before you actually lock in your bet. It's up to you to decide if the payout is worth the original wager. I like the idea though but haven't really done that on a parlay enough to see if it works out. Maybe do some imaginary bets and keep a spreadsheet of the results.