For a season comeback, possible. Best comeback ever - Bills down 35-3 to the Oilers in the playoffs in 1993 playoffs (1992 season) and coming back to win with starting QB (Jim Kelly) and starting RB (Thurman Thomas) on the bench. The immortal Frank Reich beings the Bills from behind to win the game. By the way, Reich had led the largest comeback in college history before this at Maryland (down 31-0, he brought the Terps back to win 42-40 over the U - Miami). Pretty remarkable.